CNS Drug Delivery

Drugs can be delivered to the CNS by using olfactory route prevailing between nose and brain. The Trigeminal neural pathway also may be involved in rapidly delivering protein therapeutic agents, such as insulin like growth factor-1 to the brain following intranasal administration.

CNS drugs show values of molecular weight, lipophilicity, and hydrogen bond donor and acceptor that in general have a smaller range than general therapeutics. Pharmacokinetic properties can be manipulated by the medicinal chemist to a significant extent.