Kyryl O Bocharov

Luhansk Taras Shevchenko National University

Title: Pharmaceutics 2024 The Synthesis of 2-amino-3- benzylindolizines with using the mixture of halides n-benzyl-2-halogenpyridines and CH-acids – derivatives acetonitrile

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Biography

Kyryl O. Bocharov is a scientist in the field of organic synthesis and medicinal chemistry. He is a third-year bachelor student of Applied Chemistry at IMC University of Applied Sciences Krems. Austria. He is defending his Bachelor Thesis on "Carbocyclisation of aldoses using NHC catalysis via Stetter reaction". He has many years of experience in organic synthesis of bioactive compounds, as well as in the use of modern methods of spectroscopic analysis and molecular docking. His research is focused on the development of new methods for the synthesis of organic compounds with high potential applications in medicine and academia.

Abstract

The chemistry of indolizine derivatives holds great promise for the development of potential new drugs. Both natural and synthetic indolizines have demonstrated a diverse range of pharmaceutical properties, from antitumour and antimycobacterial to antagonistic and antiproliferative activities. The discovery and strategic planning of new building blocks for the synthesis of potential indolizine compounds represents a significant breakthrough in improving and optimizing the chemical production of existing drugs. The multistep synthesis of indolizine derivatives was proposed and carried out based on Eugene Babaev's studies on the use of 2-halogenpyridinium salts. The synthesis included a modified method of benzyl bromide addition without the use of solvents, SNVin reaction with diverse symmetric and asymmetric C-nucleophiles (CH-acids) and intermolecular cyclisation by Thorpe-Ziegler. The synthesis of aryl and vinyl derivatives resulted in high yields, as confirmed and described by NMR 1H, 13C, LC-MS data and reported in our recent publication. Finally, we have developed and systematised an efficient method for synthesising potential new indolizine building blocks for further application in medicinal chemistry and cutting-edge drug design.