Prashant Mande

SM Pharmaceuticals, Sdn. Bhd., Malaysia

Title: Oral Peptide Drugs Delivery Strategies, Commercial Challenges and Future

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Biography

I am Dr. Prashant Mande, working in the pharmaceutical industry in areas of solid oral development (generic formulations), Lyophilization technology (Powder for injection), and MDI's. I am having more than 12 years of experience in Pharmaceutical industry for AND, NDA, and generic development for SEA countries.

Abstract

Proteins & Peptides (PPs) have been striking therapeutic molecules compared to conventional drugs due to their high selectivity and efficacy, but fewer side effects.

Parenteral route is the most commonly used method of administration for protein and peptide, due to poor gastrointestinal (GI) stability and limited permeability. However, short plasma half-life protein and peptide drugs requires repetitive injections and results in poor patient compliance.

Hence the oral administration of therapeutic peptides and proteins is most preferred over any other route from a patient and commercial point of view. 

Oral delivery is a promising substitute but then again PPs have to overcome numerous barriers including harsh GI environment and defensive intestinal enzymatic, mucus and epithelial barriers to reach the systemic circulation. 

Designing an oral peptide drug delivery system has been a persistent challenge furthermore because of complex physicochemical properties of molecule such as poor membrane permeability and large molecular size. 

Consequently, considering the big market demand and need of time, efforts have exhibited by variety of researches on developing new technologies to overcome physiological and physicochemical barriers of PPs. 

Numerous strategies being explored which comprise enteric coating, enzyme inhibitors, permeation enhancers, chemical modification, nanoparticles, as well as intestinal microdevices. 

Some of these new technologies being developed has been already under clinical trials evaluation. Whereas, some scientists have been achieved the commercial success and oral peptide drugs has efficaciously launched in the market.